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Morphine doesn’t just relieve pain, it has predictable system wide effects that are high yield for exams and clinical practice. Activation of μ opioid receptors leads to central nervous system depression, reduced respiratory drive, and altered autonomic tone. Respiratory depression occurs due to decreased brainstem responsiveness to carbon dioxide. Histamine release contributes to vasodilation, which explains orthostatic hypotension, flushing, and pruritus. Gastrointestinal motility is reduced v
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