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SOLVED:The Mannich reaction of a ketone, an amine, and an aldehyde is one of the few three-component reactions in organic chemistry. Cyclohexanone, for example, reacts with dimethylamine and acetaldehyde to yield an amino ketone. The reaction takes place in two steps, both of which are typical carbonyl-group reactions. (a) The first step is reaction between the aldehyde and the amine to yield an intermediate iminium ion (R2 C=NR2^ ) plus water. Propose a mechanism, and show the structure of the
SOLVED:The Mannich reaction of a ketone, an amine, and an aldehyde is one of the few three-component reactions in organic chemistry. Cyclohexanone, for example, reacts with dimethylamine and acetaldehyde to yield an amino ketone. The reaction takes place in two steps, both of which are typical carbonyl-group reactions. (a) The first step is reaction between the aldehyde and the amine to yield an intermediate iminium ion (R2 C=NR2^ ) plus water. Propose a mechanism, and show the structure of the
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