A hippocampal circuit mechanism to balance memory reactivation during sleep

The simplified pathway for memory formation occurs deep inside the medial temporal lobes. The entorhinal cortex-hippocampus circuit is critical for both the input and output of memories in humans. This circuit becomes severely damaged in Alzheimer’s disease and different forms of amnesia. Memory recall, especially of emotional memories, is often induced by an emotional stimulus which activates the amygdala and subsequently sends signals to the hippocampus. The hippocampus is responsible for both