The rookie running back did not practice last week and has been officially ruled out of Sunday’s clash at Hard Rock stadium ...

RB Jordan Mason filled in admirably to start the year, but he was hit with a shoulder injury in Week 6 that he battled until ...

The San Francisco 49ers are going to have a fourth different starting running back this season according to a report from ...

San Francisco 49ers running back Isaac Guerendo appeared on Wednesday's injury report due to a hamstring issue sustained ...

The 49ers will have to start their fourth different running back this Sunday against the Miami Dolphins. That's because ...

The San Francisco 49ers have been decimated by injuries all year, specifically at the running back position. Christian ...

Coach Kyle Shanahan said Monday that the 49ers expect Guerendo (foot/hamstring) to practice Thursday, Nick Wagoner of ESPN.com reports.

ESPN insider Adam Schefter reported that San Francisco 49ers rookie running back Isaac Guerendo is unlikely to play against ...

Well this isn't good. 49ers rookie Isaac Guerendo is nursing a new injury. Kyle Shanahan revealed Guerendo was held out of ...

San Francisco 49ers running back Isaac Guerendo. / Bob Kupbens-Imagn Images The San Francisco 49ers are already down Jordan Mason and Christian McCaffrey in their backfield (both are on injured ...

Reporting emerged earlier on Thursday noting that 49ers running back Isaac Guerendo is unlikely to play in Sunday's game ...

If the San Francisco 49ers want to defend their NFC West title, they must defeat the Los Angeles Rams in Week 15. However, the team enters Thursday Night Footba ...