eLife2d
Developmental oligodendrocytes regulate brain function through the mediation of synchronized spontaneous activity
In this valuable manuscript, authors ablate cerebellar oligodendrocytes during postnatal development and show that synchrony of calcium transients in Purkinje neurons and behaviours are affected even ...
JD Supra8d
Federal Circuit Affirms PTAB Decision Regarding DNA Sampling Patent
On January 6, 2025, the United States Court of Appeals for the Federal Circuit (“CAFC”) affirmed the decision of the Patent Trial and Appeal ...
eLife3d
mTOR inhibition in Q175 Huntington’s disease model mice facilitates neuronal autophagy and mutant huntingtin clearance
This study presents a valuable finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is solid. However, the ...
Nature27d
Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB
Animals were killed by asphyxiation in a CO 2 chamber. The tumors or scar tissues were fixed in 4% paraformaldehyde at room temperature for 24 h. The specimens were cut into sections 4 μm in ...
Frontiers29d
The mechanosensitive Piezo1 channels contribute to the arterial medial calcification
After washing with DPBS (Dulbecco’s Phosphate Buffered Saline, 14190144, Gibco, Waltham, MA, United States) the cells were fixed in 4% paraformaldehyde (16005, Sigma, Burlington, MA, United States) ...
The EMBO Journal15h
PIF/harbinger transposon-derived protein promotes 7SL expression to enhance pathogen resistance
The PIF/Harbinger-derived ADF-IL protein recruits KAT2B to drive its nuclear translocation and local chromatin acetylation, ...