The adenine base editor corrected the most common mutation associated with Stargardt disease in the ABCA4 gene with no off-target effects.

Maintaining oral health is crucial for overall well-being, yet many individuals overlook the importance of proper dental care ...

- Encouraging progress supports near-term focus on lead wholly-owned program, CX-2051 (EpCAM PROBODY® ADC). Initial Phase 1a clinical data in advanced metastatic colorectal cancer (CRC) are ...

Environmental pollution from micro and nanoplastics (MNPs) poses significant global health risks due to their durability and accumulation in bodily tissues.

Huch’s pancreatic organoids are now a promising avenue for disease modeling and generating precision medicines to treat ...

Despite recent therapeutic breakthroughs, cancer patients continue to face high recurrence and mortality rates due to treatment resistance. Cancer stem cells (CSCs), a subpopulation with self-renewal ...

Cell competition in epithelial tissue eliminates transformed cells expressing activated oncoproteins to maintain epithelial homeostasis. Although the process is now understood to be of mechanochemical ...

During the development of the olfactory epithelium (OE), olfactory sensory neurons (OSNs) express only one member of the odorant receptor (OR) gene family, and O ...

To test how RANK–RANKL signalling directly affects intestinal epithelial cells, we exposed mouse and human intestinal organoids (self-organized 3D tissues derived from intestine-resident stem ...

Their emerging links to human diseases?" published in TrAC Trends in Analytical Chemistry, investigators collected 61 available research articles for MNP detection in human tissues, plus 840 ...

Intestines suffer a lot of wear and tear in their daily service to digestion ... the regulation of gene expression in intestinal epithelial cells. They also used 3D organoid samples, scaled-down human ...

Institute of Translational Medicine, Faculty of Health Sciences & Ministry of Education Frontiers Science Center for Precision Oncology, University of Macau, Taipa 999078, Macau, China ...