Using CRISPR to decipher whether gene variants lead to cancer
In recent years, scientists have created a range of new methods based on CRISPR-Cas technology for precisely editing the ...
Stem cells can tailor their role in gene therapy based on the underlying disease, study suggests
RCCS San Raffaele Scientific Institute in Milan researchers have discovered that hematopoietic stem cells (HSCs) adapt their lineage commitment during gene therapy based on the underlying genetic ...
The American Journal of Managed Care28d
CNS-Directed AAV Gene Therapy: Immune Dynamics and Clinical Implications
CNS-directed AAV gene therapy shows milder immune responses compared to systemic ... via IP delivery exhibited minimal changes in B-cell responses, regardless of baseline anti-AAV titers or ...
University of Pennsylvania gene therapy spinout Interius BioTherapeutics doses patient, achieves CAR therapy first
Its lead gene therapy candidate has the potential to be faster, less expensive, and more widely available than current CAR T ...
News Medical1mon
Gene editing enhances immunotherapy success by preventing T-cell exhaustion
"We discovered that disrupting the Axsl1 gene in T cells resulted in a better response to immune checkpoint blockade ... Transplantation and Cellular Therapy. T cells that encounter too many ...
Disrupting Asxl1 gene prevents T-cell exhaustion to improve immunotherapy, researchers discover
"We discovered that disrupting the Axsl1 gene in T cells resulted in a better response to immune checkpoint blockade ...
Labroots29d
Cell & Gene Therapy Virtual Event Series 2024
Expect in-depth discussions covering revolutionary technologies used for precision genome editing, advancements and innovations in immune effector cell therapies, and the growing role or AI in gene ...
FierceBiotech29d
New cell therapy biotech emerges with $17M, thymus-targeting therapies
Cell therapy biotech Tolerance Bio has unveiled with $17.2 million and a mission of targeting immune diseases by stretching and saving the function of a key organ. The Philadelphia biotech’s ...
The Week1d
How innovations in CAR T-Cell therapy pave way for broader and safer cancer treatment
To improve long-term persistence and reduce the risk of immune rejection, researchers are exploring ways to diminish the ...
Business Insider8d
Genprex to present positive preclinical data from Reqorsa Gene Therapy study
Genprex (GNPX) announced that its research collaborators at Meharry Medical College will present a poster detailing positive preclinical data from a study of the Company’s lead drug candidate, Reqorsa ...
Yahoo Finance8d
Ensoma Unveils Three Programs Leveraging In Vivo Hematopoietic Stem Cell Engineering Platform to Target Genetic, Immune and Oncological Diseases
from single base edits up to large multi-gene insertions. Importantly, the platform leverages HSCs as a self-renewing reservoir of engineered cells, providing durable therapies with improved patient ...
Science Daily1mon
Disrupting Asxl1 gene prevents T-cell exhaustion, improving immunotherapy
Disrupting the Asxl1 gene in T cells enhanced response to immune checkpoint blockade and ... of Bone Marrow Transplantation and Cellular Therapy. T cells that encounter too many tumor cell pieces ...