Thorax

Antifibrotic therapy and lung cancer risk in patients with idiopathic pulmonary fibrosis: a large retrospective propensity-weighted cohort study

Background Antifibrotic (AF) therapy has been shown to potentially reduce the risk of lung cancer (LC) in patients with ...
Thorax

New pathogenic PTPN2 variant leading to childhood interstitial lung disease

Protein tyrosine phosphatase non-receptor type 2 ( PTPN2 ) is a tyrosine phosphatase involved in T cell receptor signal ...
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Mucin 5B promoter polymorphism is associated with idiopathic pulmonary fibrosis but not with development of lung fibrosis in systemic sclerosis or sarcoidosis

3 Clinical Trials and Evaluation Unit, Royal Brompton and Harefield NHS Foundation Trust, London, UK 4 Department of Radiology, Royal Brompton Hospital and National Heart and Lung Institute, Imperial ...
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Thrombocytosis is associated with increased short and long term mortality after exacerbation of chronic obstructive pulmonary disease: a role for antiplatelet therapy?

Introduction Evidence suggests that platelets play a significant role in inflammation in addition to their role in thrombosis. Systemic inflammation is linked to poor short and long term outcomes in ...
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Elastic parametric response mapping: quantitative CT scoring for local COPD severity

Background Current quantitative chest CT techniques improve chronic obstructive pulmonary disease (COPD) phenotyping but do not capture spatial variability and potentially reversible disease in local ...
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Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study

5 Division of Respiratory Medicine, Nottingham City Hospital, Nottingham NG5 1PB, UK Correspondence to: Dr J T Macfarlane, Respiratory Infection Research Group, Respiratory Medicine, Nottingham City ...
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Online First

Sex differences in outcome after endoscopic lung volume reduction (ELVR) in patients with emphysema: a retrospective analysis of the German Lung Emphysema Registry (LER e.V.) ...
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P272 Epidemiology of idiopathic pulmonary fibrosis in the uk: findings from the british lung foundation’s ‘respiratory health of the nation’ project

Introduction and objectives The last comprehensive survey of UK respiratory disease epidemiology was the British Thoracic Society’s 2006 Burden of Lung Disease report. We performed an analysis ...
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Lung cancer survival and stage at diagnosis in Australia, Canada, Denmark, Norway, Sweden and the UK: a population-based study, 2004–2007

Background The authors consider whether differences in stage at diagnosis could explain the variation in lung cancer survival between six developed countries in 2004–2007. Methods Routinely collected ...
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Azithromycin for prevention of exacerbations in severe asthma (AZISAST): a multicentre randomised double-blind placebo-controlled trial

1 Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium 2 Department of Respiratory Medicine, OLV Ziekenhuis, Aalst, Belgium 3 Department of Respiratory Medicine, AZ Groeninge, ...
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Mortality, survival and incidence rates in the ITALUNG randomised lung cancer screening trial

Background ITALUNG is contributing to the European evaluation of low-dose CT (LDCT) screening for lung cancer (LC). Methods Eligible subjects aged 55–69 years, smokers or ex-smokers (at least 20 ...