and these systems have demonstrated their utility for genetic dissection of disease mechanisms (Shulman et al. 2003 ). For example, when expressed in the Drosophila brain, Tau protein—which forms ...

More than 40 Drosophila melanogaster genes have been ... loss of the mouse orthologue in the brain has been shown to cause neurodegeneration, and loss-of-function mutations in the human orthologue ...