Microsoft Excel comes with a lot of built-in functionality that doesn't restrict you to comparing data in two columns using only one method.

Use a built-in rule or a formula rule to compare two lists of Excel values.

How to compare columns in Microsoft Excel As stated, we can use the Excel VLOOKUP function to find and match different data or find differences in two columns.

If you need to reconcile batches of records in Microsoft Excel, this simple VLOOKUP() solution offers a quick and easy way to find records in one batch that are missing from another.