Hyperrelexic, overactive or spastic bladder or bowels occur with spinal cord injury at or above T12. The primary characteristic of this type of injury is increased organ spasms. The UMN bladder may ...

PMA was diagnosed on the basis of presence of pure lower motor neuron findings at the initial visit. Of the 91 patients originally diagnosed with PMA, 20 subsequently developed upper motor neuron ...

Motor neurone disease (MND ... ALS affects both the upper motor neurones that travel from the brain to the spinal cord and the lower motor neurones, which branch out to the various muscle groups ...

University of Wisconsin–Madison researchers targeting a group of hereditary neurodegenerative diseases have found success ...

Motor neurone disease is a group of diseases that ... known as the "spastic paraplegias", where the malfunction is in the upper part of the spinal cord. Dr Emma Baple, also from the University ...

Degenerative cervical myelopathy (DCM) is a clinical condition of upper motor neuron lesion signs, that is confirmed with advanced imaging demonstrating compression of the spinal cord in the cervical ...

ALS is caused by the loss of upper motor neurons, located in the brain, and lower motor neurons, which extend from the spinal cord to the muscles. Using a genetically modified mouse model, Chantelle ...

More information: Olivia Escudier et al, Evaluation of a Synthetic Retinoid, Ellorarxine, in the NSC-34 Cell Model of Motor Neuron Disease, International Journal of Molecular Sciences (2024). DOI ...