In a study published in the Clinical and Translational Medicine, a Nanjing University research group evaluated the on- and off-target effects of self-assembled siRNA delivery system. RNA interference ...
At the end of 2023, the FDA approved Casgevy for sickle cell disease, its first approval for a therapeutic that used the genome editing tool clustered regulatory interspaced palindromic repeats ...
CRISPR-Cas9 gene editing technology is widely used to to help study genes of interest and modify disease-associated genes. However, the system is associated with adverse effects, including mutations ...
Transfection is a method used to introduce nucleic acids into mammalian and insect cells. This technique has been used for a wide variety of applications involving protein expression and/or gene ...
Researchers introduce Variant-aware Cas-OFFinder, a web-based tool that improves CRISPR off-target predictions by incorporating individual genetic differences. By reconstructing allele-specific ...
Thought LeadersDr. Amir SheikhiAssistant ProfessorChemical Engineering and Biomedical EngineeringThe Pennsylvania State University AZoNano speaks with Dr. Amir Sheikhi from The Pennsylvania State ...
Nausea and, to a lesser extent, vomiting are among the most common adverse effects associated with all the three FDA-approved PARP inhibitors (olaparib, niraparib, and rucaparib) in patients with ...
In a new study published in the Clinical and Translational Medicine, the research group of Prof. Chen-Yu Zhang and Prof. Xi Chen at Nanjing University evaluated the on- and off-target effects of ...
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