A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing is a ...

Researchers at the Centre for Genomic Regulation (CRG) in Barcelona have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine inside every cell. The ...

To sustain life, processes in biological cells have to be strictly controlled both in time and in space. Researchers have elucidated a previously unknown mechanism that regulates one of the essential ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...

Pre-mRNA splicing is a fundamental step in mRNA maturation and its discovery in 1977 revolutionized our understanding of gene expression. This collection includes reviews and research articles from ...

After a decade of work, scientists have completed a molecular model of the human spliceosome, an incredibly complex cellular machine. When an active gene is expressed in a cell, it is transcribed into ...

Watching fruit flies buzz around the ripe bananas in your kitchen, you might think it’s a tad ludicrous, mortifying even, that humans have a similar number of genes—about 23,000—as the lowly insects.

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...

"A functioning spliceosome is a basic prerequisite for healthy cells, tissue and the entire organism," she concluded. "Additional investigation of the stress signalling programme we have identified ...

Gene transcription produces pre-messenger RNAs (pre-mRNA) that are composed of exons and introns as the first RNA species. Subsequent splicing consists of the deletion of introns and the specific ...

From neurosurgery to bar code readers, lasers have been used in a myriad of applications since they were first introduced in the late 1950’s. Now, with the work being done in Jeff Gelles’ Lab at ...