In a study published in Nature Methods, a research group developed a highly sensitive proteomics method called peptide-centric local stability assay (PELSA), which enables the simultaneous ...

Drug designers working on protein-level chemistry have long been blocked by a hard computational wall: classical ...

Sphingosine-1-phosphate receptors are the targets for treating many human diseases and selectivity is one of the major hindrances during drug development. Two crystal structures of human sphingosine-1 ...

The proteins found in nature represent only a tiny fraction of the nearly limitless protein structures that could theoretically exist. By designing proteins de novo—from scratch—scientists can more ...

A new method that successfully designs serine hydrolase enzymes capable of catalyzing ester hydrolysis with high efficiency, demonstrates a computational approach for creating de novo enzymes that ...

Ligand-based drug design is transforming pharmaceutical discovery by enabling researchers to identify promising therapeutics without requiring complete structural data on biological targets. Modern AI ...

Sino Biological, Inc. (Shenzhen Stock Exchange:301047.SZ) has announced that its gene synthesis and cell-free protein expression workflow was used in a recent study by Tencent AI for Life Sciences Lab ...

CAMBRIDGE, England & BOSTON & VILLIGEN, Switzerland--(BUSINESS WIRE)--Nuclera, the biotechnology company enabling rapid access to high-quality proteins and leadXpro, a specialist in structure-based ...

How did the earliest life on Earth build complex biological machinery with so few tools? A new study explores how the simplest building blocks of proteins—once limited to just half of today's amino ...