Defects in the oxidative phosphorylation (OXPHOS) system — the final biochemical pathway in the production of ATP — result in devastating, mainly multisystem diseases. The OXPHOS system is ...

A critical factor in this devastating disease is the metabolic reprogramming exhibited by cancer cells, particularly the preference for aerobic glycolysis over oxidative phosphorylation ...

There is substantial evidence that differential cancer cell metabolism, and oxidative phosphorylation (OxPhos) in particular, plays a key role in the development of resistance to current therapies.

This unleashes transcription of mtDNA genes involved in oxidative phosphorylation, producing the much-needed ATP. Neuronal excitation triggers an influx of calcium into mitochondria, triggering ...

Mitoribosomes are present in the mitochondria of all eukaryotic cells. Their function is to allow the translation of mitochondrial mRNA that exclusively encodes components of the oxidative ...