Precision and timing of gene expression is essential for normal biological functions and, when disrupted, can lead to many human diseases, including cancers. However, how molecular machines—protein ...

Comprehensive Genomic Assessment of Advanced-Stage GI Stromal Tumors Using the Japanese National Center for Cancer Genomics and Advanced Therapeutics Database We analyzed the genomic and immune ...

Aggregates of α-synuclein are the hallmark of synucleinopathies such as Parkinson’s disease and dementia with Lewy bodies, but could other protein inclusions contribute to pathology? Yes, say ...

Researchers have found that the stability of a protein next to its nuclear localization signal sequence impacts the rate of its entry into the nucleus. Recent research from The Francis Crick Institute ...

Uncovering the mystery of why individuals born with mutations in the gene that encodes HSL—the cytosolic enzyme that releases energy from fat—lose fat instead of gaining it, Dominique Langin, PhD, ...