NMDA receptors are ionotropic glutamate receptors that mediate excitatory neurotransmission and underpin synaptic plasticity, learning and memory. Their unique voltage-dependent block by magnesium and ...

A research team has identified a molecular mechanism that coordinates the operation of the N-methyl-D-aspartate (NMDA) glutamate receptor, which is key to regulating excitatory synapse function in the ...

Researchers have identified a promising new therapeutic strategy for autism spectrum disorder (ASD). A research team led by ...

Researchers restored NMDA receptor function by targeting SLC6A20 in autism models. In animal studies, the treatment improved ...

A new study reveals that targeting the SLC6A20 glycine transporter with ASOs restores NMDAR function and reverses adult autism behaviors.

The research team at the Institute for Basic Science (IBS) has presented a new therapeutic strategy that could improve the ...

When it comes to brain proteins, small changes can make a dramatic difference. Researchers studying NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and moment-by-moment ...

When it comes to brain proteins, small changes can make a dramatic difference. Researchers studying NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and moment-by-moment ...

Consider two seemingly unrelated medical puzzles. First: Every day, our bodies produce hundreds of billions of new cells, many of which are mutated. If cancer arises from cellular mutation, why don't ...

Neurons generated from stem cells (from skin fibroblasts) of a patient with sporadic Alzheimer’s disease. Visualized with a specific green fluorescent marker. Nuclei are shown in blue. Researchers ...

Northwestern Medicine scientists have discovered that suppressing excitatory synaptic transmission in a small group of ...