A new study has, for the first time, settled the debate about how a mutated protein present in half of all human cancers drives tumor growth. The discovery will not only facilitate a rethink of the ...

Research from the Federal University of Rio de Janeiro (UFRJ) and the National Institute of Science and Technology for Structural Biology and Bioimaging (INBEB) in Brazil has uncovered a critical ...

Mutations of the tumor suppressor p53 not only have a growth-promoting effect on the cancer cells themselves, but also influence the cells in the tumor's microenvironment. Scientists have now shown ...

A new editorial was published in Oncotarget's Volume 15 on October 1, 2024, entitled, "Transplant or no transplant for TP53 mutated AML." As highlighted in this editorial, TP53 mutations (mut) occur ...

The p53 tumor suppressor protein is encoded by TP53, the most frequently mutated gene in cancer. A review article published in Nature Reviews Clinical Oncology by Professor Klas G Wiman and colleagues ...

Researchers have solved a mystery about the most important driver of cancer development - a mutant protein found in half of all cancers - and how it contributes to tumor growth. Researchers from WEHI ...

mRNA injections could reduce aggressive ovarian tumors by rescuing an often mutated gene in high-grade serous ovarian patients, according to a preclinical study. The most common form of ovarian cancer ...

Ovarian cancer is often very aggressive and responds poorly to the therapies currently available. A recent study by Goethe University Frankfurt and University Hospital Frankfurt offers hope that this ...

Autologous T-Cell Therapies in Solid Tumor Malignancies: Current Landscape and Future Opportunities Histology-agnostic therapies: by focusing on common mutations across various cancers, this approach ...