The choice of which therapeutic alternatives to compare drugs against will be foundational in Medicare’s drug price negotiation, now and in future years. We believe a broad approach to the selection ...

The Biden administration has walked back a last-minute bid by its predecessor to give Part D plans the ability to restrict access to certain classes of drugs such as antidepressants. The Centers for ...

First-in-class drugs can be highly innovative because of their novel mechanisms of action, but they also carry uncertainty in the absence of clinical experience. To understand how such drugs advance ...

Individuals with HIV who were resistant to all four antiretroviral drug classes experienced higher mortality than those who were not resistant, a difference primarily due to lower CD4 cell counts.

Researchers looked specifically at head-to-head randomized clinical trials of next-in-class cancer drugs against existing agents in the same class. Less than one-quarter of next-in-class cancer drugs ...