Biomanufacturing might appear to be centered around the cell line, which does enjoy a certain pride of place, ensconced as it is in the bioreactor, where conditions are carefully monitored and ...

Despite the importance of downstream bioprocessing, there are many opportunities for improvement, according to a report by Alois Jungbauer, PhD, a retired professor of biotechnology at the University ...

Authors: Nick Koumakis and Rut Besseling. Protein aggregation in downstream processing (DSP) is a product-quality concern and major process-performance issue. Aggregate populations can reduce ...

Upstream titers of 3–5 g/L, and up to 10–13 g/L, are outpacing downstream capacity, creating chromatography, filtration, and UF/DF throughput bottlenecks that elevate cost and delay timelines. Complex ...