Endless possibility is not a notion easily conveyed in video games. Sandbox titles like Grand Theft Auto seem limitless at first, but that illusion disappears once you discover their boundaries.

Karl Lagerfeld, who continues to churn out provocative political cartoons for Frankfurter Allgemeine Zeitung, relies on his Faber-Castell pencil crayons. Now he has designed the ultimate set: a ...

Harjes: So if you have your crayon box out, start drawing a snake. Macaluso: Exactly. But they're used for signalling. Essentially, something will bind to the outside of that receptor, outside of the ...