Complement component 3, often called C3, is an essential protein of the immune system. This protein plays a vital role in the body’s innate immune system, providing: the first line of defense against ...

Please provide your email address to receive an email when new articles are posted on . Kim’s hypothesis arises partially from studies that showed that C3, when introduced to synthetic neutrophils, ...

Circulating cold-insoluble complexes, observed in 11 of 31 patients with systemic lupus erythematosus (SLE), consisted mainly of immunoglobulin G and the C′lq component of complement and did not ...

A prospective cohort study evaluating complement and platelet activation among lupus patients with antiphospholipid syndrome. Problem: There is a high rate of obstetrical complications, such as ...

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The complement system is part of the body's immune system to fight pathogens and remove cell debris; its role in two autoimmune diseases and a mental disorder is a surprise Variants in a gene of the ...

Restoring the bodys balance between the actions of antibodies and natural regulatory proteins is the goal of a therapy being developed for the autoimmune disease lupus. This treatment thwarts ...

A gamma-globulin factor in the serum of patients with systemic lupus erythematosus that reacts with isolated cell nuclei 1 or nucleoprotein 2,3 has been detected in many ways. 4 The standard method of ...

We found evidence of linkage at 1q32.2 in a targeted genome scan of 1q21-43 in 126 lupus multiplex families containing 151 affected sibpairs (nonparametric linkage score 2.52, P = 0.006). A positional ...

Mentor: Brad H. Rovin, MD, FACP, FASN, Director of Nephrology, Professor of Medicine and Pathology, The Lee A. Hebert Professor of Nephrology, Director, the Ohio State University, Clinical Management ...