Uncovering a secret room that a giant virus creates inside its host amoeba

A virus relies on the host's translation machinery to replicate itself and become infectious. Translation efficiency ...
Nature

How viral RNAs escape a host mechanism that controls translation

This is a summary of: Liu. H. et al. Viral RNA blocks circularization to evade host codon usage control. Nature https://doi.org/10.1038/s41586-025-09809-y (2025).
AZoLifeSciences on MSN

Deep learning–based codon optimization framework boosts protein expression in E coli

By combining Transformer-based sequence modeling with a novel conditional probability strategy, the approach overcomes ...

Unusual genetic code in Antarctic microbes yields rare amino acid

Researchers discover a unique genetic code in Antarctic archaea that encodes a rare amino acid, potentially advancing protein ...
Science Daily

It's all in the code: Protein production efficiency can be predicted by gene sequence

Scientists explored mRNA and protein public databases to unravel hidden meanings of the genetic code. Using a metric derived from mRNA codon composition, they found out how gene sequence choice can ...
eLife

Separating selection from mutation in antibody language models

This important study introduces a new biology-informed strategy for deep learning models aiming to predict mutational effects in antibody sequences. It provides solid evidence that separating ...
EurekAlert!

The secret room a giant virus creates inside its host amoeba

A virus relies on the host's translation machinery to replicate itself and become infectious. Translation efficiency ...