The transition from single-celled organisms to multicellular life was a pivotal moment in evolutionary history, marking the emergence of complex communication systems that allow cells to coordinate ...

Mitochondrial calcium signaling is crucial for energy metabolism and calcium homeostasis, but monitoring it accurately is challenging due to pH fluctuations. Existing GECIs are often sensitive to pH ...

Cerebral blood delivery depends on mechanisms such as electrical signaling, which propagates through capillary networks to upstream arterioles to deliver blood, and calcium signaling, which fine-tunes ...

Calcium signalling is a pivotal regulatory mechanism in ciliated protozoa, orchestrating a myriad of cellular processes from ciliary beating to membrane trafficking. Recent studies have illuminated ...

Calcium (Ca 2+) drives many cellular functions, though the way it controls quality of proteins in the endoplasmic reticulum (ER), a cellular organelle that synthesizes and transports proteins, is ...

Background: Wnt signaling affects fundamental development pathways by regulating cell proliferation and differentiation. Aberrant activation of Wnt/ß-catenin signaling promotes the development of ...

The field of mathematical modelling of calcium signalling dynamics has evolved into an essential interdisciplinary area that bridges applied mathematics, computational simulation and cell biology.

This influx of calcium at the contact site attracts and activates a kinase called CaMKII, a protein known to be important in memory. CaMKII alters the plasma membrane's biochemical properties, ...

Glycine, a non-essential amino acid derived from serine, plays an increasingly recognized role in metabolic regulation. Epidemiological studies consistently show that reduced circulating glycine ...

Navigating the world is no mean feat, especially when the world pushes back. For instance, airflow hitting a fly on its right ...

To navigate, the brain must convert changing sensations into a map-like sense of the world, which remains stable as the body moves. A new study finds that the fly brain sometimes performs the ...