Fort Wayne is a city in and the county seat of Allen County, Indiana, United States. Located in northeastern Indiana, the city is 18 miles w…Fort Wayne is a city in and the county seat of Allen County, Indiana, United States. Located in northeastern Indiana, the city is 18 miles west of the Ohio border and 50 miles south of the Michigan border. The city's population was 263,886 as of the 2020 census, making it the second-most populous city in Indiana after Indianapolis, and the 83rd-most populous city in the United States. It is the principal city of the Fort Wayne metropolitan area, consisting of Allen and Whitley counties which had an estimated population of 423,038 as of 2021. Fort Wayne is the cultural and economic center of northeastern Indiana.